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stimulates skeletal and somatic growth, and activates metabolic reactions and regeneration processes rein the body. It slows the synthesis of fats and stimulates muscle growth.
The vermittels-protocol Reihe (PPS) was a subset of the FAS that included all subjects without any major protocol deviations. The FAS welches the main data Serie for the evaluation of efficacy. Both ITT and PPS were analyzed to prevent selection bias. Safety data analyses were performed on a safety Serie (SS) that included all subjects who had received the study drug at least once rein the treatment group and all subjects in the control group after randomization.
Increase rein mean height welches observed hinein both study groups across all evaluable time points (Figure 2B), with those hinein the treatment group experiencing larger gain rein height compared with untreated subjects. △height welches statistically significantly higher in the treatment group compared with control at all time points (P < 0.
In Figure 2C, animals that received 1 mg/kg/week of Jintrolong® for 52 weeks exhibit severe CP vacuolation compared to the 26-week group at the same dose in Figure 1B, which indicates that Jintrolong®-induced vacuolation increases with time and underscores the need for long-term studies to examine the effects of Jintrolong®-induced CP vacuolation.
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To determine whether vacuolation causes excessive cell proliferation, the Ausprägung of Ki-67 welches detected by IHC. Ki-67 is a common proliferation marker used to identify non-G0 phase cells and can thus identify cells undergoing mitosis.
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Since vacuolation did not obviously affect the subcellular structure or cell proliferation of CP epithelial cells, the next question is whether the vacuolation hinein CP affected the function of CP epithelial cells and the brain. The indices of CP function measured were secreted CSF and cell metabolism of glucose.
The daily rhGH Jintropin, provided by GeneScience Pharmaceuticals, is rhGH without any PEGylation and was used as a control hinein the clinical trials.
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: When a Endbenutzer types a query, he or she is trying to accomplish something. We refer to this goal as the Endanwender intent.”
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